Neurobiology of Disease Altered Neuron Excitability and Synaptic Plasticity in the Cerebellar Granular Layer of Juvenile Prion Protein Knock- Out Mice with Impaired Motor Control
نویسندگان
چکیده
Francesca Prestori,1 Paola Rossi,1 Bertrand Bearzatto,3 Jeanne Lainé,4 Daniela Necchi,2 Shyam Diwakar,1 Serge N. Schiffmann,3 Herbert Axelrad,4 and Egidio D’Angelo1 1Department of Molecular/Cellular Physiology and Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, and 2Department of Animal Biology, University of Pavia, 27100 Pavia, Italy, 3Laboratoire de Neurophysiologie (CP601), Faculté de Médecine, Université Libre de Bruxelles, B-1070 Bruxelles, Belgium, and 4Laboratory of Cerebellar Neurobiology, Faculté de Médecine Pitiê-Salpétrière, 75013 Paris, France
منابع مشابه
Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control.
Although the role of abnormal prion protein (PrP) conformation in generating infectious brain diseases (transmissible spongiform encephalopathy) has been recognized, the function of PrP in the normal brain remains mostly unknown. In this investigation, we considered the effect of PrP gene knock-out (PrP(0/0)) on cerebellar neural circuits and in particular on granule cells, which show intense P...
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